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DNA Methylation, Epigenetics and Metastasis By Manel Esteller

This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs.

• Hardcover: 322 pages
• Publisher: Springer; 1 edition (July 21, 2005)
• Language: English
• ISBN-10: 1402036418
• ISBN-13: 978-1402036415

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